This case study was published in Gut Microbes Reports in Fall 2024. Reprinted with permission. Reviewed by Patricia Kaufman, PhD, LDN, CNS, MS, MBA
ACHS Assistant Professor Patricia Kaufman, PhD, LDN, CNS, MS, MBA was the lead author of a groundbreaking case report published in Gut Microbes Reports. The study, titled “Preventing chemotherapy-induced diarrhea and microbiota imbalances with prebiotics and probiotics in breast cancer treatment” explores the role of prebiotics and probiotics in maintaining gut microbiota health and reducing digestive adverse effects during chemotherapy for breast cancer, shedding light on how integrative approaches can reduce adverse effects caused by cancer treatments
The Challenge: Chemotherapy-Induced Diarrhea and Gut Dysbiosis
Breast cancer remains the most common cancer affecting women in the U.S., with nearly 300,000 new cases annually. Chemotherapy, a vital treatment for many patients, can lead to a debilitating side effect: chemotherapy-induced diarrhea (CID). Affecting up to 80% of patients, CID can result in severe dehydration, nutrient loss, and gut microbiota imbalance. These disruptions often lead to treatment delays, compounding health risks.
Traditional treatments, such as antidiarrheal medications, can sometimes worsen gut health by promoting the growth of harmful bacteria. Thus, exploring alternative strategies like prebiotics and probiotics is vital to managing these side effects and supporting overall well-being.
The Case Report: A Personalized Approach to Gut Health
The report details the journey of a 57-year-old breast cancer patient who sought to mitigate chemotherapy side effects while preserving gut health. With a history of irritable bowel syndrome (IBS), the patient worked closely with an integrative care team to develop a personalized plan.
Using advanced gut microbiota testing, the team assessed the patient’s bacterial diversity and tailored a regimen of prebiotics and probiotics. Key elements of the protocol included:
- Prebiotics: SunFiber, partially hydrolyzed guar gum (PHGG) and lactulose were used to enhance beneficial bacteria and improve gut function.
- Probiotics: Specific strains such as Lactobacillus rhamnosus GG, Bifidobacterium lactis, and S. Bourlardii, were chosen for their ability to reduce diarrhea, promote gut lining repair, and maintain bacterial diversity.
The patient also followed a Mediterranean-style diet, rich in fiber, polyphenols, and nutrients, while incorporating additional support like exercise, acupuncture, and stress management.
Results and Insights
Over the course of treatment, microbiota testing revealed significant improvements in the patient’s gut health:
- A notable increase in beneficial Bifidobacterium levels (1.3 x increase from starting treatment).
- Enhanced bacterial diversity, despite some temporary declines during chemotherapy.
- No chemotherapy adverse effects of diarrhea and improved overall gut function.
These findings highlight the potential of prebiotics and probiotics to counteract the adverse effects of chemotherapy on gut health.
Why This Matters
The case report underscores the importance of a holistic, integrative approach to cancer treatment. By addressing gut health, patients may experience fewer side effects, better treatment adherence, and improved quality of life. While more research is needed, this study paves the way for using prebiotics and probiotics as supportive therapies in oncology care.
Read the full case report here: https://tinyurl.com/mttf3f97
At ACHS, we are proud to celebrate the innovative work of faculty members like Dr. Kaufman, who continue to expand the boundaries of integrative health. This research exemplifies our commitment to blending evidence-based science with holistic approaches for better health outcomes.
For more insights into holistic health and wellness, explore programs and resources at ACHS.
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This content is for educational purposes only and is not intended to be medical advice. It is not intended to treat, diagnose, cure, or prevent disease. This article has not been reviewed by the FDA. Always consult with your primary care physician or naturopathic doctor before making any significant changes to your health and wellness routine.
